Potential greater than additive vasorelaxant actions of milrinone and nitroglycerin on human conduit arteries
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چکیده
منابع مشابه
Paradoxical Normoxia-Dependent Selective Actions of Inorganic Nitrite in Human Muscular Conduit Arteries, and Related Selective Actions on Central Blood Pressures Running title: Omar et al.; Nitrite - Selective Dilator of Conduit Arteries
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متن کاملCoronary Arteries by Nitroglycerin
Vasodilatory responses of segments of large epicardial left coronary artery (CA), small intramyocardial CAs (0.3-1.0 mm), coronary stenoses and CAs filled by collaterals were determined in 34 patients. Measurements were made before and after nitroglycerin (0.4 mg, sublingual) by means of quantitative magnification coronary angiography using photospot film and a calibrated 6-power viewing device...
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We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chemical reactions. We examine to what extent this statistical model predicts synergy effects of cooperative activation of gene expression. We determine parameter domains in which greater-than-additive and less-than-additive effects are predicted for cooperative regulation by two activators. We show ...
متن کاملAgeing of the conduit arteries.
Conduit arteries become stiffer with age due to alterations in their morphology and the composition of the their major structural proteins, elastin and collagen. The elastic lamellae undergo fragmentation and thinning, leading to ectasia and a gradual transfer of mechanical load to collagen, which is 100-1000 times stiffer than elastin. Possible causes of this fragmentation are mechanical (fati...
متن کاملParadoxical normoxia-dependent selective actions of inorganic nitrite in human muscular conduit arteries and related selective actions on central blood pressures.
BACKGROUND Inorganic nitrite dilates small resistance arterioles via hypoxia-facilitated reduction to vasodilating nitric oxide. The effects of nitrite in human conduit arteries have not been investigated. In contrast to nitrite, organic nitrates are established selective dilators of conduit arteries. METHODS AND RESULTS We examined the effects of local and systemic administration of sodium n...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1996
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1996.tb00166.x